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Brain-stiffness-mimicking tilapia collagen gel promotes the induction of dorsal cortical neurons from human pluripotent stem cells

The mechanical properties of the extracellular microenvironment, including its stiffness, play a crucial role in stem cell fate determination. Although previous studies have demonstrated that the developing brain exhibits spatiotemporal diversity in stiffness, it remains unclear how stiffness regula...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Iwashita, Misato, Ohta, Hatsumi, Fujisawa, Takahiro, Cho, Minyoung, Ikeya, Makoto, Kidoaki, Satoru, Kosodo, Yoichi
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2019
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6395773/
https://ncbi.nlm.nih.gov/pubmed/30816128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-38395-5
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