Exploiting the vulnerable active site of a copper-only superoxide dismutase to disrupt fungal pathogenesis

Copper-only superoxide dismutases (SODs) represent a new class of SOD enzymes that are exclusively extracellular and unique to fungi and oomycetes. These SODs are essential for virulence of fungal pathogens in pulmonary and disseminated infections, and we show here an additional role for copper-only...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Robinett, Natalie G., Culbertson, Edward M., Peterson, Ryan L., Sanchez, Hiram, Andes, David R., Nett, Jeniel E., Culotta, Valeria C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6393590/
https://ncbi.nlm.nih.gov/pubmed/30593499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.007095
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