Ibudilast sensitizes glioblastoma to temozolomide by targeting Macrophage Migration Inhibitory Factor (MIF)

Recurrence in patients with glioblastoma (GBM) is inevitable resulting in short survival times, even in patients with O-6-Methylguanine-DNA Methyltransferase (MGMT) methylation. Other pathways must be activated to escape from temozolomide (TMZ) treatment, however acquired resistance mechanisms to TM...

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Udgivet i:Sci Rep
Main Authors: Ha, Wendy, Sevim-Nalkiran, Hatice, Zaman, Ashraf M., Matsuda, Kazuko, Khasraw, Mustafa, Nowak, Anna K., Chung, Liping, Baxter, Robert C., McDonald, Kerrie L.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6393433/
https://ncbi.nlm.nih.gov/pubmed/30814573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-39427-4
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