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The reduced form of coagulation factor XI is associated with illness severity and coagulopathy in critically-ill septic patients
BACKGROUND. Coagulation Factor XI (FXI) contributes to the pathobiology of sepsis-associated thrombosis and is a target for new therapeutics. Through cleavage of disulfide bonds, FXI becomes reduced (rFXI), accelerating intrinsic coagulation cascade activation. The role of rFXI in human sepsis has n...
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| Publicado no: | J Thromb Thrombolysis |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6393197/ https://ncbi.nlm.nih.gov/pubmed/30600428 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11239-018-1797-9 |
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