Assessment of electrophile damage in a human brain endothelial cell line utilizing a clickable alkyne analogue of 2-chlorohexadecanal

Peripheral leukocytes aggravate brain damage by releasing cytotoxic mediators that compromise blood-brain barrier function. One of the oxidants released by activated leukocytes is hypochlorous acid (HOCl) that is formed via the myeloperoxidase-H(2)O(2)-chloride system. The reaction of HOCl with the...

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Publicado no:Free Radic Biol Med
Main Authors: Nusshold, Christoph, Üllen, Andreas, Kogelnik, Nora, Bernhart, Eva, Reicher, Helga, Plastira, Ioanna, Glasnov, Toma, Zangger, Klaus, Rechberger, Gerald, Kollroser, Manfred, Fauler, Günter, Wolinski, Heimo, Weksler, Babette B., Romero, Ignacio A., Kohlwein, Sepp D., Couraud, Pierre-Olivier, Malle, Ernst, Sattler, Wolfgang
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6392177/
https://ncbi.nlm.nih.gov/pubmed/26577177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2015.11.010
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