Precise and Rapid Validation of Candidate Gene by Allele Specific Knockout With CRISPR/Cas9 in Wild Mice

It is a tempting goal to identify causative genes underlying phenotypic differences among inbred strains of mice, which is a huge reservoir of genetic resources to understand mammalian pathophysiology. In particular, the wild-derived mouse strains harbor enormous genetic variations that have been ac...

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Udgivet i:Front Genet
Main Authors: Chao, Tianzhu, Liu, Zhuangzhuang, Zhang, Yu, Zhang, Lichen, Huang, Rong, He, Le, Gu, Yanrong, Chen, Zhijun, Zheng, Qianqian, Shi, Lijin, Zheng, Wenping, Qi, Xinhui, Kong, Eryan, Zhang, Zhongjian, Lawrence, Toby, Liang, Yinming, Lu, Liaoxun
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2019
Fag:
Genetics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6390232/
https://ncbi.nlm.nih.gov/pubmed/30838037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2019.00124
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