Developmental Comparison of Ceramide in Wild-Type and Cln3(Δex7/8) Mouse Brains and Sera

CLN3 disease is a neurodevelopmental disease leading to early visual failure, motor decline, and death. CLN3 pathogenesis has been linked to dysregulation of ceramide, a key intracellular messenger impacting various biological functions. Ceramide is upregulated in brains of CLN3 patients and activat...

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Detalhes bibliográficos
Publicado no:Front Neurol
Main Authors: El-Sitt, Sally, Soueid, Jihane, Al Ali, Jamal, Makoukji, Joelle, Makhoul, Nadine J., Harati, Hayat, Boustany, Rose-Mary
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Neurology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6389635/
https://ncbi.nlm.nih.gov/pubmed/30837943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fneur.2019.00128
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