Calcium Influx through Plasma-Membrane Nanoruptures Drives Axon Degeneration in a Model of Multiple Sclerosis

Axon loss determines persistent disability in multiple sclerosis patients. Here, we use in vivo calcium imaging in a multiple sclerosis model to show that cytoplasmic calcium levels determine the choice between axon loss and survival. We rule out the endoplasmic reticulum, glutamate excitotoxicity,...

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Détails bibliographiques
Publié dans:Neuron
Auteurs principaux: Witte, Maarten E., Schumacher, Adrian-Minh, Mahler, Christoph F., Bewersdorf, Jan P., Lehmitz, Jonas, Scheiter, Alexander, Sánchez, Paula, Williams, Philip R., Griesbeck, Oliver, Naumann, Ronald, Misgeld, Thomas, Kerschensteiner, Martin
Format: Artigo
Langue:Inglês
Publié: Cell Press 2019
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6389591/
https://ncbi.nlm.nih.gov/pubmed/30686733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2018.12.023
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