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Lipid–Protein Interactions in Niemann–Pick Type C Disease: Insights from Molecular Modeling
The accumulation of lipids in the late endosomes and lysosomes of Niemann–Pick type C disease (NPCD) cells is a consequence of the dysfunction of one protein (usually NPC1) but induces dysfunction in many proteins. We used molecular docking to propose (a) that NPC1 exports not just cholesterol, but...
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| Udgivet i: | Int J Mol Sci |
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| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
MDPI
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6387118/ https://ncbi.nlm.nih.gov/pubmed/30736449 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20030717 |
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