Structural insights into FTO’s catalytic mechanism for the demethylation of multiple RNA substrates

FTO demethylates internal N(6)-methyladenosine (m(6)A) and N(6),2′-O-dimethyladenosine (m(6)A(m); at the cap +1 position) in mRNA, m(6)A and m(6)A(m) in snRNA, and N(1)-methyladenosine (m(1)A) in tRNA in vivo, and in vitro evidence supports that it can also demethylate N(6)-methyldeoxyadenosine (6mA...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Zhang, Xiao, Wei, Lian-Huan, Wang, Yuxin, Xiao, Yu, Liu, Jun, Zhang, Wei, Yan, Ning, Amu, Gubu, Tang, Xinjing, Zhang, Liang, Jia, Guifang
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2019
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6386707/
https://ncbi.nlm.nih.gov/pubmed/30718435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1820574116
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