IL-27 confers a protumorigenic activity of regulatory T cells via CD39

Expression of ectonucleotidase CD39 contributes to the suppressive activity of Foxp3(+) regulatory T cells (Tregs) by hydrolyzing immunogenic ATP into AMP. The molecular mechanism that drives CD39 expression on Tregs remains elusive. We found that tumor-infiltrating Tregs (Ti-Tregs) failed to up-reg...

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Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Park, Young-Jun, Ryu, Heeju, Choi, Garam, Kim, Byung-Seok, Hwang, Eun Sook, Kim, Hun Sik, Chung, Yeonseok
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2019
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6386675/
https://ncbi.nlm.nih.gov/pubmed/30718407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1810254116
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