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IL-27 confers a protumorigenic activity of regulatory T cells via CD39
Expression of ectonucleotidase CD39 contributes to the suppressive activity of Foxp3(+) regulatory T cells (Tregs) by hydrolyzing immunogenic ATP into AMP. The molecular mechanism that drives CD39 expression on Tregs remains elusive. We found that tumor-infiltrating Tregs (Ti-Tregs) failed to up-reg...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6386675/ https://ncbi.nlm.nih.gov/pubmed/30718407 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1810254116 |
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