GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia

Cannabis use is a heritable trait that has been associated with adverse mental health outcomes. In the largest genome-wide association study for lifetime cannabis use to date (N=184,765), we identified 8 genome-wide significant independent single nucleotide polymorphisms in 6 regions. All measured g...

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Publicado en:Nat Neurosci
Autores principales: Pasman, Joëlle A., Verweij, Karin J.H., Gerring, Zachary, Stringer, Sven, Sanchez-Roige, Sandra, Treur, Jorien L., Abdellaoui, Abdel, Nivard, Michel G., Baselmans, Bart M.L., Ong, Jue-Sheng, Ip, Hill F., van der Zee, Matthijs D., Bartels, Meike, Day, Felix R., Fontanillas, Pierre, Elson, Sarah L., de Wit, Harriet, Davis, Lea K., MacKillop, James, Derringer, Jaime L., Branje, Susan J.T., Hartman, Catharina A., Heath, Andrew C., van Lier, Pol A.C., Madden, Pamela A.F., Mägi, Reedik, Meeus, Wim, Montgomery, Grant W., Oldehinkel, A.J., Pausova, Zdenka, Ramos-Quiroga, Josep A., Paus, Tomas, Ribases, Marta, Kaprio, Jaakko, Boks, Marco P.M., Bell, Jordana T., Spector, Tim D., Gelernter, Joel, Boomsma, Dorret I., Martin, Nicholas G., MacGregor, Stuart, Perry, John R.B., Palmer, Abraham A., Posthuma, Danielle, Munafò, Marcus R., Gillespie, Nathan A., Derks, Eske M., Vink, Jacqueline M.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6386176/
https://ncbi.nlm.nih.gov/pubmed/30150663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41593-018-0206-1
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