GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia

Cannabis use is a heritable trait that has been associated with adverse mental health outcomes. In the largest genome-wide association study for lifetime cannabis use to date (N=184,765), we identified 8 genome-wide significant independent single nucleotide polymorphisms in 6 regions. All measured g...

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Publié dans:Nat Neurosci
Auteurs principaux: Pasman, Joëlle A., Verweij, Karin J.H., Gerring, Zachary, Stringer, Sven, Sanchez-Roige, Sandra, Treur, Jorien L., Abdellaoui, Abdel, Nivard, Michel G., Baselmans, Bart M.L., Ong, Jue-Sheng, Ip, Hill F., van der Zee, Matthijs D., Bartels, Meike, Day, Felix R., Fontanillas, Pierre, Elson, Sarah L., de Wit, Harriet, Davis, Lea K., MacKillop, James, Derringer, Jaime L., Branje, Susan J.T., Hartman, Catharina A., Heath, Andrew C., van Lier, Pol A.C., Madden, Pamela A.F., Mägi, Reedik, Meeus, Wim, Montgomery, Grant W., Oldehinkel, A.J., Pausova, Zdenka, Ramos-Quiroga, Josep A., Paus, Tomas, Ribases, Marta, Kaprio, Jaakko, Boks, Marco P.M., Bell, Jordana T., Spector, Tim D., Gelernter, Joel, Boomsma, Dorret I., Martin, Nicholas G., MacGregor, Stuart, Perry, John R.B., Palmer, Abraham A., Posthuma, Danielle, Munafò, Marcus R., Gillespie, Nathan A., Derks, Eske M., Vink, Jacqueline M.
Format: Artigo
Langue:Inglês
Publié: 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6386176/
https://ncbi.nlm.nih.gov/pubmed/30150663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41593-018-0206-1
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