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Contribution of 3′T and 3′TT overhangs to the thermodynamic stability of model siRNA duplexes
Herein, we report comprehensive thermodynamic studies on 36 RNA/DNA duplexes designed as siRNA mimics to determine the energetic contribution of 3′T and 3′TT dangling ends. The thermodynamic effect induced by the presence of 3′T overhangs on the stability of RNA duplexes ranges from −0.28 to −0.92 k...
में बचाया:
| में प्रकाशित: | Biophys Chem |
|---|---|
| मुख्य लेखकों: | , , |
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
2019
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6386172/ https://ncbi.nlm.nih.gov/pubmed/30660935 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpc.2018.12.006 |
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