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Contribution of 3′T and 3′TT overhangs to the thermodynamic stability of model siRNA duplexes

Herein, we report comprehensive thermodynamic studies on 36 RNA/DNA duplexes designed as siRNA mimics to determine the energetic contribution of 3′T and 3′TT dangling ends. The thermodynamic effect induced by the presence of 3′T overhangs on the stability of RNA duplexes ranges from −0.28 to −0.92 k...

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Foilsithe in:Biophys Chem
Main Authors: Lisowiec-Wachnicka, Jolanta, Znosko, Brent M., Pasternak, Anna
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2019
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6386172/
https://ncbi.nlm.nih.gov/pubmed/30660935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpc.2018.12.006
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