ADAMTS9 Regulates Skeletal Muscle Insulin Sensitivity Through Extracellular Matrix Alterations

The ADAMTS9 rs4607103 C allele is one of the few gene variants proposed to increase the risk of type 2 diabetes through an impairment of insulin sensitivity. We show that the variant is associated with increased expression of the secreted ADAMTS9 and decreased insulin sensitivity and signaling in hu...

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書誌詳細
出版年:Diabetes
主要な著者: Graae, Anne-Sofie, Grarup, Niels, Ribel-Madsen, Rasmus, Lystbæk, Sara H., Boesgaard, Trine, Staiger, Harald, Fritsche, Andreas, Wellner, Niels, Sulek, Karolina, Kjolby, Mads, Backe, Marie Balslev, Chubanava, Sabina, Prats, Clara, Serup, Annette K., Birk, Jesper B., Dubail, Johanne, Gillberg, Linn, Vienberg, Sara G., Nykjær, Anders, Kiens, Bente, Wojtaszewski, Jørgen F.P., Larsen, Steen, Apte, Suneel S., Häring, Hans-Ulrich, Vaag, Allan, Zethelius, Björn, Pedersen, Oluf, Treebak, Jonas T., Hansen, Torben, Holst, Birgitte
フォーマット: Artigo
言語:Inglês
出版事項: American Diabetes Association 2019
主題:
Metabolism
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6385758/
https://ncbi.nlm.nih.gov/pubmed/30626608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db18-0418
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