ADAMTS9 Regulates Skeletal Muscle Insulin Sensitivity Through Extracellular Matrix Alterations

The ADAMTS9 rs4607103 C allele is one of the few gene variants proposed to increase the risk of type 2 diabetes through an impairment of insulin sensitivity. We show that the variant is associated with increased expression of the secreted ADAMTS9 and decreased insulin sensitivity and signaling in hu...

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Detalhes bibliográficos
Publicado no:Diabetes
Main Authors: Graae, Anne-Sofie, Grarup, Niels, Ribel-Madsen, Rasmus, Lystbæk, Sara H., Boesgaard, Trine, Staiger, Harald, Fritsche, Andreas, Wellner, Niels, Sulek, Karolina, Kjolby, Mads, Backe, Marie Balslev, Chubanava, Sabina, Prats, Clara, Serup, Annette K., Birk, Jesper B., Dubail, Johanne, Gillberg, Linn, Vienberg, Sara G., Nykjær, Anders, Kiens, Bente, Wojtaszewski, Jørgen F.P., Larsen, Steen, Apte, Suneel S., Häring, Hans-Ulrich, Vaag, Allan, Zethelius, Björn, Pedersen, Oluf, Treebak, Jonas T., Hansen, Torben, Holst, Birgitte
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2019
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6385758/
https://ncbi.nlm.nih.gov/pubmed/30626608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db18-0418
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