ADAMTS9 Regulates Skeletal Muscle Insulin Sensitivity Through Extracellular Matrix Alterations

The ADAMTS9 rs4607103 C allele is one of the few gene variants proposed to increase the risk of type 2 diabetes through an impairment of insulin sensitivity. We show that the variant is associated with increased expression of the secreted ADAMTS9 and decreased insulin sensitivity and signaling in hu...

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Bibliografski detalji
Izdano u:Diabetes
Glavni autori: Graae, Anne-Sofie, Grarup, Niels, Ribel-Madsen, Rasmus, Lystbæk, Sara H., Boesgaard, Trine, Staiger, Harald, Fritsche, Andreas, Wellner, Niels, Sulek, Karolina, Kjolby, Mads, Backe, Marie Balslev, Chubanava, Sabina, Prats, Clara, Serup, Annette K., Birk, Jesper B., Dubail, Johanne, Gillberg, Linn, Vienberg, Sara G., Nykjær, Anders, Kiens, Bente, Wojtaszewski, Jørgen F.P., Larsen, Steen, Apte, Suneel S., Häring, Hans-Ulrich, Vaag, Allan, Zethelius, Björn, Pedersen, Oluf, Treebak, Jonas T., Hansen, Torben, Holst, Birgitte
Format: Artigo
Jezik:Inglês
Izdano: American Diabetes Association 2019
Teme:
Metabolism
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6385758/
https://ncbi.nlm.nih.gov/pubmed/30626608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db18-0418
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