Loss of Nuclear and Membrane Estrogen Receptor-α Differentially Impairs Insulin Secretion and Action in Male and Female Mice

Estrogens favor glucose homeostasis primarily through the estrogen receptor-α (ERα), but the respective importance of nuclear ERα (NOER) and membrane ERα (MOER) pools to glucose homeostasis are unknown. We studied glucose homeostasis, insulin secretion, and insulin sensitivity in male and female mic...

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Detalhes bibliográficos
Publicado no:Diabetes
Main Authors: Allard, Camille, Morford, Jamie J., Xu, Beibei, Salwen, Benjamin, Xu, Weiwei, Desmoulins, Lucie, Zsombok, Andrea, Kim, Jason K., Levin, Ellis R., Mauvais-Jarvis, Franck
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2019
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6385757/
https://ncbi.nlm.nih.gov/pubmed/30305367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db18-0293
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