Effect of Apolipoprotein E4 on clinical, neuroimaging and biomarker measures in non-carrier participants in the Dominantly Inherited Alzheimer Network

The apolipoprotein E ε4 allele (APOE4) is the major genetic risk factor for sporadic Alzheimer Disease (AD). APOE4 may have effects on cognition and brain atrophy years before the onset of symptomatic AD. We analyzed the effects of APOE4 in a unique cohort of young adults who had undergone comprehen...

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Библиографические подробности
Опубликовано в: :Neurobiol Aging
Главные авторы: Bussy, Aurélie, Snider, B. Joy, Coble, Dean, Xiong, Chengjie, Fagan, Anne M., Cruchaga, Carlos, Benzinger, Tammie L.S., Gordon, Brian A., Hassenstab, Jason, Bateman, Randall J., Morris, John C.
Формат: Artigo
Язык:Inglês
Опубликовано: 2018
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6385602/
https://ncbi.nlm.nih.gov/pubmed/30530186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2018.10.011
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