P-glycoprotein Inhibitor Tariquidar Potentiates Efficacy of Astragaloside IV in Experimental Autoimmune Encephalomyelitis Mice

ATP-binding cassette (ABC) transporters, such as P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP), often reduce drug efficacy and are the major cause of drug resistance. Astragaloside IV (ASIV), one of the bioactive saponins isolated from Astragalus membranaceus, has been demonstrat...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Zhang, Wei, Liu, Mei, Yang, Liu, Huang, Fei, Lan, Yunyi, Li, Hongli, Wu, Hui, Zhang, Beibei, Shi, Hailian, Wu, Xiaojun
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6384695/
https://ncbi.nlm.nih.gov/pubmed/30717494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24030561
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