Synthesis and Biological Evaluation of Quinoline Derivatives as a Novel Class of Broad-Spectrum Antibacterial Agents

Nineteen new quinoline derivatives were prepared via the Mannich reaction and evaluated for their antibacterial activities against both Gram-positive (G(+)) and Gram-negative (G(−)) bacteria, taking compound 1 as the lead. Among the target compounds, quinolone coupled hybrid 5d exerted the potential...

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Udgivet i:Molecules
Main Authors: Fu, Hai-Gen, Li, Zhi-Wen, Hu, Xin-Xin, Si, Shu-Yi, You, Xue-Fu, Tang, Sheng, Wang, Yan-Xiang, Song, Dan-Qing
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6384568/
https://ncbi.nlm.nih.gov/pubmed/30717338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24030548
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