Contrasting Roles of the PD-1 Signaling Pathway in Dendritic Cell-Mediated Induction and Regulation of HIV-1-Specific Effector T Cell Functions

Eliciting highly functional CD8(+) cytotoxic T lymphocyte (CTL) responses against a broad range of epitopes will likely be required for immunotherapeutic control of HIV-1 infection. However, the combination of CTL exhaustion and the ability of HIV-1 to rapidly establish CTL escape variants presents...

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Pubblicato in:J Virol
Autori principali: Garcia-Bates, Tatiana M., Palma, Mariana L., Shen, Chengli, Gambotto, Andrea, Macatangay, Bernard J. C., Ferris, Robert L., Rinaldo, Charles R., Mailliard, Robbie B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2019
Soggetti:
Cellular Response to Infection
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6384070/
https://ncbi.nlm.nih.gov/pubmed/30541848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02035-18
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