Mitochondrial hypoxic stress induces widespread RNA editing by APOBEC3G in natural killer cells

BACKGROUND: Protein recoding by RNA editing is required for normal health and evolutionary adaptation. However, de novo induction of RNA editing in response to environmental factors is an uncommon phenomenon. While APOBEC3A edits many mRNAs in monocytes and macrophages in response to hypoxia and int...

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Detalhes bibliográficos
Publicado no:Genome Biol
Main Authors: Sharma, Shraddha, Wang, Jianmin, Alqassim, Emad, Portwood, Scott, Cortes Gomez, Eduardo, Maguire, Orla, Basse, Per H., Wang, Eunice S., Segal, Brahm H., Baysal, Bora E.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6383285/
https://ncbi.nlm.nih.gov/pubmed/30791937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-019-1651-1
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