Mitochondrial hypoxic stress induces widespread RNA editing by APOBEC3G in natural killer cells

BACKGROUND: Protein recoding by RNA editing is required for normal health and evolutionary adaptation. However, de novo induction of RNA editing in response to environmental factors is an uncommon phenomenon. While APOBEC3A edits many mRNAs in monocytes and macrophages in response to hypoxia and int...

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Dettagli Bibliografici
Pubblicato in:Genome Biol
Autori principali: Sharma, Shraddha, Wang, Jianmin, Alqassim, Emad, Portwood, Scott, Cortes Gomez, Eduardo, Maguire, Orla, Basse, Per H., Wang, Eunice S., Segal, Brahm H., Baysal, Bora E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2019
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6383285/
https://ncbi.nlm.nih.gov/pubmed/30791937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-019-1651-1
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