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APOL1 polymorphisms and kidney disease: loss-of-function or gain-of-function?

The mechanism that explains the association of APOL1 variants with nondiabetic kidney diseases in African Americans remains unclear. Kidney disease risk is inherited as a recessive trait, and many studies investigating the intracellular function of APOL1 have indicated the APOL1 variants G1 and G2 a...

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書目詳細資料
發表在:Am J Physiol Renal Physiol
Main Authors: Bruggeman, Leslie A., O’Toole, John F., Sedor, John R.
格式: Artigo
語言:Inglês
出版: American Physiological Society 2019
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6383195/
https://ncbi.nlm.nih.gov/pubmed/30332315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00426.2018
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