The Safety, Tolerability, and Effects on the Systemic Inflammatory Response and Renal Function of the Human Chorionic Gonadotropin Hormone-Derivative EA-230 Following On-Pump Cardiac Surgery (The EASI Study): Protocol for a Randomized, Double-Blind, Placebo-Controlled Phase 2 Study

BACKGROUND: The cardiac surgery–induced systemic inflammatory response may induce postoperative hemodynamic instability and impairment of renal function. EA-230, a linear tetrapeptide (A-Q-G-V), is derived from the beta chain of the human chorionic gonadotropin pregnancy hormone. It has shown immuno...

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Detalhes bibliográficos
Publicado no:JMIR Res Protoc
Main Authors: van Groenendael, Roger, Beunders, Remi, Hofland, Jan, Morshuis, Wim J, Kox, Matthijs, van Eijk, Lucas T, Pickkers, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: JMIR Publications 2019
Assuntos:
Protocol
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6381408/
https://ncbi.nlm.nih.gov/pubmed/30724734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2196/11441
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