Rho-kinase inhibitor coupled to peptide-modified albumin carrier reduces portal pressure and increases renal perfusion in cirrhotic rats

Rho-kinase (ROCK) activation in hepatic stellate cells (HSC) is a key mechanism promoting liver fibrosis and portal hypertension (PTH). Specific delivery of ROCK-inhibitor Y-27632 (Y27) to HSC targeting mannose-6-phosphate-receptors reduces portal pressure and fibrogenesis. In decompensated cirrhosi...

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Publicado en:Sci Rep
Main Authors: Klein, Sabine, Frohn, Franziska, Magdaleno, Fernando, Reker-Smit, Catharina, Schierwagen, Robert, Schierwagen, Irela, Uschner, Frank Erhard, van Dijk, Fransien, Fürst, Dieter O., Djudjaj, Sonja, Boor, Peter, Poelstra, Klaas, Beljaars, Leonie, Trebicka, Jonel
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6381202/
https://ncbi.nlm.nih.gov/pubmed/30783172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-38678-5
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