Activation of mTORC1 in subchondral bone preosteoblasts promotes osteoarthritis by stimulating bone sclerosis and secretion of CXCL12

Increasing evidences show that aberrant subchondral bone remodeling plays an important role in the development of osteoarthritis (OA). However, how subchondral bone formation is activated and the mechanism by which increased subchondral bone turnover promotes cartilage degeneration during OA remains...

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Detalhes bibliográficos
Publicado no:Bone Res
Main Authors: Lin, Chuangxin, Liu, Liangliang, Zeng, Chun, Cui, Zhong-Kai, Chen, Yuhui, Lai, Pinling, Wang, Hong, Shao, Yan, Zhang, Haiyan, Zhang, Rongkai, Zhao, Chang, Fang, Hang, Cai, Daozhang, Bai, Xiaochun
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6381187/
https://ncbi.nlm.nih.gov/pubmed/30792936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41413-018-0041-8
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