Dihydroartemisinin inhibits prostate cancer via JARID2/miR-7/miR-34a-dependent downregulation of Axl

Axl expression is deregulated in several cancer types, predicts poor overall patient survival and is linked to resistance to drug therapy. Here, we evaluated a library of natural compounds for inhibitors of Axl and identified dihydroartemisinin, the active principle of the anti-malarial drug artemis...

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Détails bibliographiques
Publié dans:Oncogenesis
Auteurs principaux: Paccez, Juliano D., Duncan, Kristal, Sekar, Durairaj, Correa, Ricardo G., Wang, Yihong, Gu, Xuesong, Bashin, Manoj, Chibale, Kelly, Libermann, Towia A., Zerbini, Luiz F.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2019
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6381097/
https://ncbi.nlm.nih.gov/pubmed/30783079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41389-019-0122-6
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