Evidence for Highly Variable, Region-Specific Patterns of T-Cell Epitope Mutations Accumulating in Mycobacterium tuberculosis Strains

Vaccines that confer protection through induction of adaptive T-cell immunity rely on understanding T-cell epitope (TCE) evolution induced by immune escape. This is poorly understood in tuberculosis (TB), an ancient, chronic disease, where CD4 T-cell immunity is of recognized importance. We probed 9...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Ramaiah, Arunachalam, Nayak, Soumya, Rakshit, Srabanti, Manson, Abigail L., Abeel, Thomas, Shanmugam, Sivakumar, Sahoo, Pravat Nalini, John, Anto Jesuraj Uday Kumar, Sundaramurthi, Jagadish Chandrabose, Narayanan, Sujatha, D'Souza, George, von Hoegen, Paul, Ottenhoff, Tom H. M., Swaminathan, Soumya, Earl, Ashlee M., Vyakarnam, Annapurna
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6381025/
https://ncbi.nlm.nih.gov/pubmed/30814998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.00195
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