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Subunits of the mechano-electrical transduction channel, Tmc1/2b, require Tmie to localize in zebrafish sensory hair cells

Mutations in transmembrane inner ear (TMIE) cause deafness in humans; previous studies suggest involvement in the mechano-electrical transduction (MET) complex in sensory hair cells, but TMIE’s precise role is unclear. In tmie zebrafish mutants, we observed that GFP-tagged Tmc1 and Tmc2b, which are...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Pacentine, Itallia V., Nicolson, Teresa
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6380590/
https://ncbi.nlm.nih.gov/pubmed/30726219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007635
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