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Exonuclease domain mutants of yeast DIS3 display genome instability
The exosome functions to regulate the cellular transcriptome through RNA biogenesis, surveillance, and decay. Mutations in Dis3, a catalytic subunit of the RNA exosome with separable endonuclease and exonuclease activities, are linked to multiple myeloma. Here we report that a cancer-associated DIS3...
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| Vydáno v: | Nucleus |
|---|---|
| Hlavní autoři: | , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Taylor & Francis
2019
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6380420/ https://ncbi.nlm.nih.gov/pubmed/30724665 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19491034.2019.1578600 |
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