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Paternal genome rescues mouse preimplantation embryo development in the absence of maternally-recruited EZH2 activity
Enhancer of zeste homolog 2 (EZH2), a component of the PRC2 complex, trimethylates H3K27, a transcriptionally repressive histone mark. EZH2 is encoded by a dormant maternal mRNA and inhibiting the maturation-associated increase in EZH2 activity using either a combined siRNA/morpholino approach or a...
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| Publicado no: | Epigenetics |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6380398/ https://ncbi.nlm.nih.gov/pubmed/30661456 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15592294.2019.1570771 |
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