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Phosphoglycolate has profound metabolic effects but most likely no role in a metabolic DNA response in cancer cell lines

Repair of a certain type of oxidative DNA damage leads to the release of phosphoglycolate, which is an inhibitor of triose phosphate isomerase and is predicted to indirectly inhibit phosphoglycerate mutase activity. Thus, we hypothesized that phosphoglycolate might play a role in a metabolic DNA dam...

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Dettagli Bibliografici
Pubblicato in:Biochem J
Autori principali: Gerin, Isabelle, Bury, Marina, Baldin, Francesca, Graff, Julie, Van Schaftingen, Emile, Bommer, Guido T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Portland Press Ltd. 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6380167/
https://ncbi.nlm.nih.gov/pubmed/30670572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20180435
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