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Phosphoglycolate has profound metabolic effects but most likely no role in a metabolic DNA response in cancer cell lines

Repair of a certain type of oxidative DNA damage leads to the release of phosphoglycolate, which is an inhibitor of triose phosphate isomerase and is predicted to indirectly inhibit phosphoglycerate mutase activity. Thus, we hypothesized that phosphoglycolate might play a role in a metabolic DNA dam...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Biochem J
Hauptverfasser: Gerin, Isabelle, Bury, Marina, Baldin, Francesca, Graff, Julie, Van Schaftingen, Emile, Bommer, Guido T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Portland Press Ltd. 2019
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6380167/
https://ncbi.nlm.nih.gov/pubmed/30670572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20180435
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