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Plasmid-based gap-repair recombineered transgenes reveal a central role for introns in mutually exclusive alternative splicing in Down Syndrome Cell Adhesion Molecule exon 4

Alternative splicing is a key feature of human genes, yet studying its regulation is often complicated by large introns. The Down Syndrome Cell Adhesion Molecule (Dscam) gene from Drosophila is one of the most complex genes generating vast molecular diversity by mutually exclusive alternative splici...

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Détails bibliographiques
Publié dans:Nucleic Acids Res
Auteurs principaux: Haussmann, Irmgard U, Ustaoglu, Pinar, Brauer, Ulrike, Hemani, Yash, Dix, Thomas C, Soller, Matthias
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2019
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6379703/
https://ncbi.nlm.nih.gov/pubmed/30541104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky1254
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