Plasmid-based gap-repair recombineered transgenes reveal a central role for introns in mutually exclusive alternative splicing in Down Syndrome Cell Adhesion Molecule exon 4

Alternative splicing is a key feature of human genes, yet studying its regulation is often complicated by large introns. The Down Syndrome Cell Adhesion Molecule (Dscam) gene from Drosophila is one of the most complex genes generating vast molecular diversity by mutually exclusive alternative splici...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Haussmann, Irmgard U, Ustaoglu, Pinar, Brauer, Ulrike, Hemani, Yash, Dix, Thomas C, Soller, Matthias
Format: Artigo
Language:Inglês
Published: Oxford University Press 2019
Subjects:
Molecular Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6379703/
https://ncbi.nlm.nih.gov/pubmed/30541104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky1254
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