Super-enhancer-associated MEIS1 promotes transcriptional dysregulation in Ewing sarcoma in co-operation with EWS-FLI1

As the second most common malignant bone tumor in children and adolescents, Ewing sarcoma is initiated and exacerbated by a chimeric oncoprotein, most commonly, EWS-FLI1. In this study, we apply epigenomic analysis to characterize the transcription dysregulation in this cancer, focusing on the inves...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Lin, Lehang, Huang, Moli, Shi, Xianping, Mayakonda, Anand, Hu, Kaishun, Jiang, Yan-Yi, Guo, Xiao, Chen, Li, Pang, Brendan, Doan, Ngan, Said, Jonathan W, Xie, Jianjun, Gery, Sigal, Cheng, Xu, Lin, Zhaoyu, Li, Jinsong, Berman, Benjamin P, Yin, Dong, Lin, De-Chen, Koeffler, H Phillip
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Gene regulation, Chromatin and Epigenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6379679/
https://ncbi.nlm.nih.gov/pubmed/30496486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky1207
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