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Human DNA ligase IV is able to use NAD(+) as an alternative adenylation donor for DNA ends ligation
All the eukaryotic DNA ligases are known to use adenosine triphosphate (ATP) for DNA ligation. Here, we report that human DNA ligase IV, a key enzyme in DNA double-strand break (DSB) repair, is able to use NAD(+) as a substrate for double-stranded DNA ligation. In the in vitro ligation assays, we sh...
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| Publicado en: | Nucleic Acids Res |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Oxford University Press
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6379666/ https://ncbi.nlm.nih.gov/pubmed/30496552 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky1202 |
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