Identification of FDA-approved drugs targeting the Farnesoid X Receptor

The farnesoid X receptor (FXR) belongs to the nuclear receptor family and is activated by bile acids. Multiple, chemically rather diverse, FXR agonists have been developed and several of these compounds are currently tested in clinical trials for NAFLD and cholestasis. Here, we investigated possible...

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Vydáno v:Sci Rep
Hlavní autoři: van de Wiel, Sandra M. W., Bijsmans, Ingrid T. G. W., van Mil, Saskia W. C., van de Graaf, Stan F. J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6379390/
https://ncbi.nlm.nih.gov/pubmed/30778102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-38668-7
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