HLA-DQA1-HLA-DRB1 variants confer susceptibility to pancreatitis induced by thiopurine immunosuppressants

Pancreatitis occurs in approximately 4% of patients treated with the thiopurines azathioprine or mercaptopurine. Its development is unpredictable and almost always leads to drug withdrawal. We identified inflammatory bowel disease patients who had developed pancreatitis within three months of starti...

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Bibliografiske detaljer
Udgivet i:Nat Genet
Main Authors: Heap, Graham A, Weedon, Michael N, Bewshea, Claire M, Singh, Abhey, Chen, Mian, Satchwell, Jack B, Vivian, Julian P, So, Kenji, Dubois, Patrick C, Andrews, Jane M, Annese, Vito, Bampton, Peter, Barnardo, Martin, Bell, Sally, Cole, Andy, Connor, Susan J, Creed, Tom, Cummings, Fraser R, D'Amato, Mauro, Daneshmend, Tawfique K, Fedorak, Richard N, Florin, Timothy H, Gaya, Daniel R, Greig, Emma, Halfvarson, Jonas, Hart, Alisa, Irving, Peter M, Jones, Gareth, Karban, Amir, Lawrance, Ian C, Lee, James C, Lees, Charlie, Lev-Tzion, Raffi, Lindsay, James O, Mansfield, John, Mawdsley, Joel, Mazhar, Zia, Parkes, Miles, Parnell, Kirstie, Orchard, Timothy R, Radford-Smith, Graham, Russell, Richard K, Reffitt, David, Satsangi, Jack, Silverberg, Mark S, Sturniolo, Giacomo C, Tremelling, Mark, Tsianos, Epameinondas V, van Heel, David A, Walsh, Alissa, Watermeyer, Gill, Weersma, Rinse K, Zeissig, Sebastian, Rossjohn, Jamie, Holden, Arthur L, Ahmad, Tariq
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6379053/
https://ncbi.nlm.nih.gov/pubmed/25217962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3093
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