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Biallelic CCM3 mutations cause a clonogenic survival advantage and endothelial cell stiffening
CCM3, originally described as PDCD10, regulates blood‐brain barrier integrity and vascular maturation in vivo. CCM3 loss‐of‐function variants predispose to cerebral cavernous malformations (CCM). Using CRISPR/Cas9 genome editing, we here present a model which mimics complete CCM3 inactivation in cav...
Gardado en:
| Publicado en: | J Cell Mol Med |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
John Wiley and Sons Inc.
2018
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6378188/ https://ncbi.nlm.nih.gov/pubmed/30549232 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.14075 |
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