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Dendritic remodeling of D1 neurons by RhoA/Rho-kinase mediates depression-like behavior

Depression alters the structure and function of brain reward circuitry. Preclinical evidence suggests that medium spiny neurons (MSNs) in the nucleus accumbens (NAc) undergo structural plasticity, however the molecular mechanism and behavioral significance is poorly understood. Here we report that a...

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Publicat a:Mol Psychiatry
Autors principals: Fox, Megan E., Chandra, Ramesh, Menken, Miriam S., Larkin, Emily J, Nam, Hyungwoo, Engeln, Michel, Francis, T. Chase, Lobo, Mary Kay
Format: Artigo
Idioma:Inglês
Publicat: 2018
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6378138/
https://ncbi.nlm.nih.gov/pubmed/30120419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41380-018-0211-5
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