Simultaneous Quantification of Methotrexate and Its Metabolite 7-Hydroxy-Methotrexate in Human Plasma for Therapeutic Drug Monitoring

OBJECTIVE: To establish and validate a simple, sensitive, and rapid liquid chromatography tandem mass spectrometry (LC-MS/MS) method for the determination of methotrexate (MTX) and its major metabolite 7-hydroxy-methotrexate (7-OH-MTX) in human plasma. METHOD: The chromatographic separation was achi...

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Bibliographic Details
Published in:Int J Anal Chem
Main Authors: Ren, Xinxin, Wang, Zhipeng, Yun, Yunlei, Meng, Guangyi, Zhang, Xialan, Ding, Huamin, Xu, Ying, Bai, Hansheng, Liu, Jing, Li, Xia, Gao, Shouhong, Huang, Lifeng, Chen, Wansheng
Format: Artigo
Language:Inglês
Published: Hindawi 2019
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6378003/
https://ncbi.nlm.nih.gov/pubmed/30853983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2019/1536532
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