Engineering an osmosensor by pivotal histidine positioning within disordered helices

Histidine kinases (HKs) funnel diverse environmental stimuli into a single autophosphorylation event at a conserved histidine residue. The HK EnvZ is a global sensor of osmolality and cellular acid pH. In previous studies, we discovered that osmosensing in EnvZ was mediated through osmolyte-induced...

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Published in:Structure
Main Authors: Ghosh, Madhubrata, Wang, Loo Chien, Huber, Roland, Gao, Yunfeng, Morgan, Leslie K., Tulsian, Nikhil Kumar, Bond, Peter, Kenney, Linda J., Anand, Ganesh S.
Format: Artigo
Language:Inglês
Published: 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6377431/
https://ncbi.nlm.nih.gov/pubmed/30503779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2018.10.012
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