Seamless Designs: Current Practice and Considerations for Early-Phase Drug Development in Oncology

Traditionally, drug development has evaluated dose, safety, activity, and comparative benefit in a sequence of phases using trial designs and endpoints specifically devised for each phase. Innovations in drug development seek to consolidate the phases and rapidly expand accrual with “seamless” trial...

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Vydáno v:J Natl Cancer Inst
Hlavní autoři: Hobbs, Brian P, Barata, Pedro C, Kanjanapan, Yada, Paller, Channing J, Perlmutter, Jane, Pond, Gregory R, Prowell, Tatiana M, Rubin, Eric H, Seymour, Lesley K, Wages, Nolan A, Yap, Timothy A, Feltquate, David, Garrett-Mayer, Elizabeth, Grossman, William, Hong, David S, Ivy, S Percy, Siu, Lillian L, Reeves, Steven A, Rosner, Gary L
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6376915/
https://ncbi.nlm.nih.gov/pubmed/30561713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/djy196
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