In vivo characterization of doxycycline-mediated protection of aortic function and structure in a mouse model of Marfan syndrome-associated aortic aneurysm

Aortic aneurysm is the most life-threatening complication in Marfan syndrome (MFS) patients. Doxycycline, a nonselective matrix metalloproteinases inhibitor, was reported to improve the contractile function and elastic fiber structure and organization in a Marfan mouse aorta using ex vivo small cham...

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Vydáno v:Sci Rep
Hlavní autoři: Cui, Jason Z., Lee, Ling, Sheng, Xiaoye, Chu, Fanny, Gibson, Christine P., Aydinian, Taline, Walker, David C., Sandor, George G. S., Bernatchez, Pascal, Tibbits, Glen F., van Breemen, Cornelis, Esfandiarei, Mitra
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6376062/
https://ncbi.nlm.nih.gov/pubmed/30765726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-38235-6
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