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The Role of NMDA Receptors in Alzheimer’s Disease
In Alzheimer’s disease (AD), early synaptic dysfunction is associated with the increased oligomeric amyloid-beta peptide, which causes NMDAR-dependent synaptic depression and spine elimination. Memantine, low-affinity NMDAR channel blocker, has been used in the treatment of moderate to severe AD. Ho...
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| Publicado en: | Front Neurosci |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Frontiers Media S.A.
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6375899/ https://ncbi.nlm.nih.gov/pubmed/30800052 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2019.00043 |
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