Specific Inhibition of Soluble γc Receptor Attenuates Collagen-Induced Arthritis by Modulating the Inflammatory T Cell Responses

IL-17 produced by Th17 cells has been implicated in the pathogenesis of rheumatoid arthritis (RA). It is important to prevent the differentiation of Th17 cells in RA. Homodimeric soluble γc (sγc) impairs IL-2 signaling and enhances Th17 differentiation. Thus, we aimed to block the functions of sγc b...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Lee, Byunghyuk, Jo, Yuna, Kim, Geona, Ali, Laraib Amir, Sohn, Dong Hyun, Lee, Seung-Geun, Kim, Kiseok, Shin, Euisu, Ryu, Sung Ho, Hong, Changwan
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6375885/
https://ncbi.nlm.nih.gov/pubmed/30800133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.00209
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