Specific Inhibition of Soluble γc Receptor Attenuates Collagen-Induced Arthritis by Modulating the Inflammatory T Cell Responses

IL-17 produced by Th17 cells has been implicated in the pathogenesis of rheumatoid arthritis (RA). It is important to prevent the differentiation of Th17 cells in RA. Homodimeric soluble γc (sγc) impairs IL-2 signaling and enhances Th17 differentiation. Thus, we aimed to block the functions of sγc b...

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Bibliografiske detaljer
Udgivet i:Front Immunol
Main Authors: Lee, Byunghyuk, Jo, Yuna, Kim, Geona, Ali, Laraib Amir, Sohn, Dong Hyun, Lee, Seung-Geun, Kim, Kiseok, Shin, Euisu, Ryu, Sung Ho, Hong, Changwan
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2019
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6375885/
https://ncbi.nlm.nih.gov/pubmed/30800133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.00209
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