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Mutations Induced by the Carcinogenic Pyrrolizidine Alkaloid Riddelliine in the Liver cII Gene of Transgenic Big Blue Rats

Riddelliine is a naturally occurring pyrrolizidine alkaloid that forms a number of different mononucleotide and dinucleotide adducts in DNA. It is a rodent carcinogen and a potential human hazard via food contamination. To examine the mutagenicity of riddelliine, groups of six female transgenic Big...

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Detalhes bibliográficos
Publicado no:Chem Res Toxicol
Main Authors: Mei, Nan, Heflich, Robert H., Chou, Ming W., Chen, Tao
Formato: Artigo
Idioma:Inglês
Publicado em: 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6375673/
https://ncbi.nlm.nih.gov/pubmed/15206902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx049955b
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