Association of Whole-Genome and NETRIN1 Signaling Pathway–Derived Polygenic Risk Scores for Major Depressive Disorder and White Matter Microstructure in the UK Biobank

BACKGROUND: Major depressive disorder is a clinically heterogeneous psychiatric disorder with a polygenic architecture. Genome-wide association studies have identified a number of risk-associated variants across the genome and have reported growing evidence of NETRIN1 pathway involvement. Stratifyin...

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Veröffentlicht in:Biol Psychiatry Cogn Neurosci Neuroimaging
Hauptverfasser: Barbu, Miruna C., Zeng, Yanni, Shen, Xueyi, Cox, Simon R., Clarke, Toni-Kim, Gibson, Jude, Adams, Mark J., Johnstone, Mandy, Haley, Chris S., Lawrie, Stephen M., Deary, Ian J., McIntosh, Andrew M., Whalley, Heather C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier, Inc 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6374980/
https://ncbi.nlm.nih.gov/pubmed/30197049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpsc.2018.07.006
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