LCAT Enzyme Replacement Therapy Reduces LpX and Improves Kidney Function in a Mouse Model of Familial LCAT Deficiency

Familial LCAT deficiency (FLD) is due to mutations in lecithin:cholesterol acyltransferase (LCAT), a plasma enzyme that esterifies cholesterol on lipoproteins. FLD is associated with markedly reduced levels of plasma high-density lipoprotein and cholesteryl ester and the formation of a nephrotoxic l...

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Bibliografiske detaljer
Udgivet i:J Pharmacol Exp Ther
Main Authors: Vaisman, Boris L., Neufeld, Edward B., Freeman, Lita A., Gordon, Scott M., Sampson, Maureen L., Pryor, Milton, Hillman, Emily, Axley, Milton J., Karathanasis, Sotirios K., Remaley, Alan T.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Pharmacology and Experimental Therapeutics 2019
Fag:
Drug Discovery and Translational Medicine
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6374542/
https://ncbi.nlm.nih.gov/pubmed/30563940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.118.251876
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